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An Other factors that can contribute to vitamins losing potency include: extreme temperatures exposure to light exposure to oxygen pH levels Unopened vitamin supplements are more likely to retain their potency because moisture, light, and oxygen are less likely to affect them

Where available, check the certificate of analysis for the exact content before calculating concentrations

Excessive methyl supplementation taking too much methylfolate or methyl-B12 for your needs COMT mutations slow breakdown of neurotransmitters, causing buildup when you add more methyls Histamine issues methylation can increase histamine in some people

Who could benefit from a B12 shot